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A complete of three % of Energetic material is excreted in urine as unchanged active material. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (2 %) by CYP2D6, which can be additional metabolised by conjugation. Consequently, Energetic material metabolism mediated by cytochrom